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1. (WO2015119848) TABLET FORMULATION FOR CGRP-ACTIVE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/119848 International Application No.: PCT/US2015/013672
Publication Date: 13.08.2015 International Filing Date: 30.01.2015
IPC:
C07D 221/02 (2006.01) ,A61K 31/437 (2006.01) ,A61K 9/26 (2006.01)
Applicants: JOHNSON, Mary Ann[US/US]; US (US)
ALLAIN, Leonardo Resende[US/US]; US (US)
EICKHOFF, W. Mark[US/US]; US (US)
IKEDA, Craig, B.[US/US]; US (US)
BROWN, Chad, D.[US/US]; US (US)
FLANAGAN, Francis, J., Jr.[US/US]; US (US)
NOFSINGER, Rebecca[US/US]; US (US)
MAROTA, Melanie[US/US]; US (US)
LUPTON, Lisa[US/US]; US (US)
PATEL, Paresh, B.[US/US]; US (US)
XI, Hanmi[CN/US]; US (US)
XU, Wei[US/US]; US (US)
MERCK SHARP & DOHME CORP.[US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
Inventors: JOHNSON, Mary Ann; US
ALLAIN, Leonardo Resende; US
EICKHOFF, W. Mark; US
IKEDA, Craig, B.; US
BROWN, Chad, D.; US
FLANAGAN, Francis, J., Jr.; US
NOFSINGER, Rebecca; US
MAROTA, Melanie; US
LUPTON, Lisa; US
PATEL, Paresh, B.; US
XI, Hanmi; US
XU, Wei; US
Agent: FISCHER, Eric H.; Merck Sharp & Dohme Corp. 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
Priority Data:
61/936,01905.02.2014US
62/087,36604.12.2014US
Title (EN) TABLET FORMULATION FOR CGRP-ACTIVE COMPOUNDS
(FR) FORMULATION DE COMPRIMÉ POUR COMPOSÉS ACTIFS VIS-À-VIS DU CGRP
Abstract: front page image
(EN) The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): Formula I, wherein "Ra" is independently H or -F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.
(FR) La présente invention concerne des compositions comprenant un extrudat ou une solution solide d'un composé, ou d'un sel de ce dernier, de Formule I (API) : Formule I, dans laquelle "Ra" représente indépendamment H ou -F, dans une matrice polymère soluble dans l'eau qui comprend en outre un système de désintégration permettant à un comprimé fabriqué à partir de cette dernière de se désintégrer rapidement dans l'environnement dans lequel l'API doit être libéré.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)