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1. (WO2015119841) ROLE OF IL-23 AND PD-1 IN AUTOREACTIVE IMMUNE RESPONSE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/119841    International Application No.:    PCT/US2015/013642
Publication Date: 13.08.2015 International Filing Date: 30.01.2015
IPC:
A61P 37/00 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
ZUNIGA, Luis [US/US]; (US) (NZ, US only).
CUA, Daniel, J. [US/US]; (US) (NZ, US only)
Inventors: ZUNIGA, Luis; (US).
CUA, Daniel, J.; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
61/936,234 05.02.2014 US
Title (EN) ROLE OF IL-23 AND PD-1 IN AUTOREACTIVE IMMUNE RESPONSE
(FR) RÔLE DE L'IL-23 ET DU PD-1 DANS UNE RÉPONSE IMMUNITAIRE AUTORÉACTIVE
Abstract: front page image
(EN)The present invention provides methods of screening subjects for the presence of IL-23R+/PD-1+ gamma-delta T-cells as a marker of autoreactive immune disorders, use of such identification in directing treatment, and related methods of treatment. The invention also provides use of such IL-23R+/PD-1+ gamma-delta T-cells in screening for agents useful in treating autoreactive immune disorders.
(FR)La présente invention concerne des méthodes de dépistage de sujets pour la présence de lymphocytes T gamma-delta IL-23R+/PD-1+ utilisés comme marqueur de troubles immunitaires autoréactifs, l'utilisation d'une telle identification dans la détermination du traitement, et des méthodes de traitement associées. L'invention concerne également l'utilisation de tels lymphocytes T gamma-delta IL-23R+/PD-1+ dans la recherche par criblage d'agents utiles dans le traitement de troubles immunitaires autoréactifs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)