Search International and National Patent Collections

1. (WO2015119291) VIRUS-LIKE PARTICLE

Pub. No.:    WO/2015/119291    International Application No.:    PCT/JP2015/053668
Publication Date: Fri Aug 14 01:59:59 CEST 2015 International Filing Date: Wed Feb 11 00:59:59 CET 2015
IPC: C12N 15/09
A61K 39/12
A61K 39/145
A61K 47/44
A61P 31/12
A61P 31/16
C07K 14/005
C07K 14/11
C12P 21/02
Applicants: THE INSTITUTE OF BIOLOGICAL RESOURCES
有限会社生物資源研究所
Inventors: NEROME, Kuniaki
根路銘 国昭
KURODA, Kazumichi
黒田 和道
SUGITA, Shigeo
杉田 繁夫
NEROME, Reiko
根路銘 令子
Title: VIRUS-LIKE PARTICLE
Abstract:
 Provided is a virus-like particle that can be used to provide a vaccine for preventing infectious diseases with a high immunogenicity, over a shorter period of time, and in mass volumes, and to produce a vaccine with lessened side effects such as anaphylactic shock and allergic reactions. Also provided is a method for producing said virus-like particles, and a such a vaccine. The present invention is a virus-like particle that contains a recombinant virus membrane protein, in addition to lipid of Bombyx mori origin. The virus-like particle is characterized by spikes of the recombinant virus membrane protein being densely arranged on the surface of the hollow spherical outer shells that are made from components including the lipid.