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1. (WO2015119249) MYOGENESIS ACCELERATOR, AMYOTROPHY SUPPRESSOR, MEDICINAL COMPOSITION, AND TAZ ACTIVATOR

Pub. No.:    WO/2015/119249    International Application No.:    PCT/JP2015/053400
Publication Date: Fri Aug 14 01:59:59 CEST 2015 International Filing Date: Sat Feb 07 00:59:59 CET 2015
IPC: A61K 31/5377
A61K 31/4164
A61K 31/454
A61P 21/00
A61P 21/04
A61P 21/06
A61P 43/00
C12N 15/09
C12Q 1/68
Applicants: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
国立大学法人東京医科歯科大学
Inventors: HATA, Yutaka
畑 裕
KAGECHIKA, Hiroyuki
影近 弘之
NAKAGAWA, Kentaro
中川 健太郎
ITO, Shigeru
伊藤 茂
Title: MYOGENESIS ACCELERATOR, AMYOTROPHY SUPPRESSOR, MEDICINAL COMPOSITION, AND TAZ ACTIVATOR
Abstract:
Provided are a novel myogenesis accelerator, amyotrophy suppressor, medicinal composition, and TAZ activator. The myogenesis accelerator, amyotrophy suppressor, medicinal composition, and TAZ activator according to the present invention contain as an active ingredient a compound represented by general formula (1). [In general formula (1), R1 represents a hydrogen atom or an alkyl group. R2 represents an aryl group, a heterocyclic group, an alkyl group, or the like. R3 represents -NR5R6 or -N=C-R7, R5 and R6 each independently represent a hydrogen atom, an alkyl group, or the like, or represent -C(=O)R8 or -COOR9, R7 represents -NR10R11, an aryl group, or a heterocyclic group, R8 represents a hydrogen atom, an alkyl group, or the like, R9 represents a hydrogen atom, an alkyl group, or the like, and R10 and R11 each independently represent a hydrogen atom or an alkyl group. R4 represents a cyano group or -C(=O)R12, and R12 represents an aryl group, a heterocyclic group, an alkyl group, or the like.]