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1. (WO2015118789) PEPTIDE/β-1,3-GLUCAN COMPLEX AND PRODUCTION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING PEPTIDE/β-1,3-GLUCAN COMPLEX

Pub. No.:    WO/2015/118789    International Application No.:    PCT/JP2014/084374
Publication Date: Fri Aug 14 01:59:59 CEST 2015 International Filing Date: Fri Dec 26 00:59:59 CET 2014
IPC: C07K 7/06
A61K 31/7088
A61K 39/00
A61K 39/39
A61P 37/04
C07K 7/08
C12N 15/00
Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY
独立行政法人科学技術振興機構
Inventors: SAKURAI Kazuo
櫻井 和朗
MOCHIZUKI Shin-ichi
望月 慎一
MORISHITA Hiromi
森下 博美
Title: PEPTIDE/β-1,3-GLUCAN COMPLEX AND PRODUCTION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING PEPTIDE/β-1,3-GLUCAN COMPLEX
Abstract:
This peptide/β-1,3-glucan complex contains β-1,3-glucan and a peptide/polynucleotide conjugate in which an antigenic peptide is bonded via a covalent bond to a polynucleotide or a derivative thereof. The polynucleotide or derivative thereof of the peptide/polynucleotide conjugate bonds via a hydrogen bond with β-1,3-glucan, forming a complex having a triple helix structure comprising a single molecular chain of the polynucleotide or derivative thereof and a double molecular chain of the β-1,3-glucan. Alternately, the side chain of the β-1,3-glucan and the antigenic peptide are bonded via a covalent bond created through either a cycloaddition reaction between an alkyne and an azide derivative, or a reaction between a maleimide group or a vinyl sulfone group and a thiol group.