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1. (WO2015118538) ANTI CD84 ANTIBODIES, COMPOSITIONS COMPRISING SAME AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/118538    International Application No.:    PCT/IL2015/050133
Publication Date: 13.08.2015 International Filing Date: 05.02.2015
IPC:
C07K 16/28 (2006.01)
Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD. [IL/IL]; at the Weizmann Institute of Science P.O. Box 95 7610002 Rehovot (IL)
Inventors: SHACHAR, Idit; (IL).
BINSKY, Inbal; (IL).
MAROM, Ayelet; (IL)
Agent: EHRLICH, Gal; G. E. Ehrlich (1995) LTD. 11 Menachem Begin Road 5268104 Ramat Gan (IL)
Priority Data:
61/936,361 06.02.2014 US
Title (EN) ANTI CD84 ANTIBODIES, COMPOSITIONS COMPRISING SAME AND USES THEREOF
(FR) ANTICORPS ANTI CD84, COMPOSITIONS LES COMPRENANT ET LEURS UTILISATIONS
Abstract: front page image
(EN)An isolated antibody comprising an antigen recognition domain which specifically binds CD84 and (i) down regulates the anti-apoptotic activity of stromal cells on chronic lymphocytic leukemia (CLL) cells; and/or (ii) induces mobilization of CLL cells from the bone marrow. Also provided are antibodies comprising antigen recognition domains comprising complementarity determining regions as indicated and uses thereof.
(FR)Un anticorps isolé comprenant un domaine de liaison à l'antigène, qui se lie spécifiquement à CD84 et (i) régule de manière négative l'activité anti-apoptotique de cellules stromales sur les cellules de la leucémie lymphocytaire chronique (CLL) ; et/ou (ii) induit la mobilisation de cellules CLL dans la moelle osseuse. L'invention concerne également des anticorps comprenant des domaines de liaison à l'antigène comportant des régions déterminant la complémentarité comme indiqué, et leurs utilisations.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)
Licensing availability request The applicant has requested the International Bureau to indicate the availability for licensing purposes of the invention(s) claimed in this international application