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1. (WO2015118537) MICRO-RNAS AND COMPOSITIONS COMPRISING SAME FOR THE TREATMENT AND DIAGNOSIS OF SEROTONIN-, ADRENALIN-, NORADRENALIN-, GLUTAMATE-, AND CORTICOTROPIN-RELEASING HORMONE- ASSOCIATED MEDICAL CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/118537 International Application No.: PCT/IL2015/050132
Publication Date: 13.08.2015 International Filing Date: 05.02.2015
IPC:
C12N 15/11 (2006.01) ,A61K 31/7088 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
Applicants:
YEDA RESEARCH AND DEVELOPMENT CO. LTD. [IL/IL]; At the Weizmann Institute of Science P.O. Box 95 7610002 Rehovot, IL
Inventors:
CHEN, Alon; IL
ISSLER, Orna; IL
Agent:
EHRLICH, Gal; G. E. Ehrlich (1995) Ltd. 11 Menachem Begin Road 5268104 Ramat Gan, IL
Priority Data:
61/935,91205.02.2014US
Title (EN) MICRO-RNAS AND COMPOSITIONS COMPRISING SAME FOR THE TREATMENT AND DIAGNOSIS OF SEROTONIN-, ADRENALIN-, NORADRENALIN-, GLUTAMATE-, AND CORTICOTROPIN-RELEASING HORMONE- ASSOCIATED MEDICAL CONDITIONS
(FR) MICRO-ARN ET COMPOSITIONS LES COMPRENANT POUR LE TRAITEMENT ET LE DIAGNOSTIC DE TROUBLES MÉDICAUX ASSOCIÉS À LA SÉROTONINE, À L'ADRÉNALINE, À LA NORADRÉNALINE, AU GLUTAMATE ET À L'HORMONE DE LIBÉRATION DE LA CORTICOTROPINE
Abstract:
(EN) A method of treating a bipolar disorder in a subject in need thereof is disclosed. The method comprising administering to the subject sa therapeutically effective amount of a miR-135, a precursor thereof or a nucleic acid molecule encoding said miR-135 or said precursor thereof, thereby treating the bipolar disorder. Methods of diagnosing a mood disorder in a human subject and of monitoring treatment of an anti-depressant drug or a medicament for the treatment of a mood disorder are also disclosed.
(FR) La présente invention concerne un procédé permettant de traiter un trouble bipolaire chez un patient nécessitant un tel traitement. Le procédé comprend l'administration au sujet d'une quantité thérapeutiquement efficace d'un miR-135, d'un précurseur de celui-ci ou d'une molécule d'acide nucléique codant pour ledit miR-135 ou ledit précurseur de celui-ci, ce qui permet de traiter le trouble bipolaire. Des procédés de diagnostic d'un trouble de l'humeur chez un sujet humain et de surveillance du traitement d'un médicament anti-dépresseur ou d'un médicament pour le traitement d'un trouble de l'humeur sont également décrits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)