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1. (WO2015118474) PROCESS FOR THE PURIFICATION OF FLUTICASONE PROPIONATE USING A KETONE SOLVENT AND WATER AS ANTI-SOLVENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/118474    International Application No.:    PCT/IB2015/050871
Publication Date: 13.08.2015 International Filing Date: 05.02.2015
IPC:
C07J 31/00 (2006.01)
Applicants: MYLAN LABORATORIES LTD. [IN/IN]; Plot No 564/a/22, Road No 92, Jubilee Hills Hyderabad 500033 (IN)
Inventors: JADHAV, Sakharam; (IN).
BOHARA, Chandersingh; (IN).
WAGH, Ghanshyam; (IN).
GORE, Vinayak Govind; (IN).
GADAKAR, Maheshkumar; (IN)
Agent: MANISHA SINGH, Nair; (IN)
Priority Data:
572/CHE/2014 07.02.2014 IN
Title (EN) PROCESS FOR THE PURIFICATION OF FLUTICASONE PROPIONATE USING A KETONE SOLVENT AND WATER AS ANTI-SOLVENT
(FR) PROCÉDÉ DE PURIFICATION DE PROPIONATE DE FLUTICASONE UTILISANT UN SOLVANT À BASE DE CÉTONE ET DE L'EAU COMME ANTI-SOLVANT
Abstract: front page image
(EN)The present disclosure relates to an improved process for the purification of fluticasone propionate by: a) dissolving fluticasone propionate in a ketone solvent to produce a mixture, b) heating the mixture slowly for 1-2 hours to get a clear solution, c) adding water to the step (b) solution at 50-60°C, d) cooling to -5°C to 10°C, and e) isolating fluticasone propionate.
(FR)La présente invention concerne un procédé amélioré de purification de propionate de fluticasone consistant : a) à dissoudre du propionate de fluticasone dans un solvant à base de cétone pour produire un mélange, b) à chauffer le mélange lentement durant 1-2 heures pour obtenir une solution claire, c) à ajouter de l'eau à la solution de l'étape (b) à 50-60°C, d) à refroidir à -5°C à 10°C, et e) à isoler le propionate de fluticasone.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)