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1. (WO2015118115) DIAGNOSIS OF A NEUROLOGICAL DISEASE

Pub. No.:    WO/2015/118115    International Application No.:    PCT/EP2015/052529
Publication Date: Fri Aug 14 01:59:59 CEST 2015 International Filing Date: Sat Feb 07 00:59:59 CET 2015
IPC: G01N 33/68
C07K 16/00
G01N 33/564
Applicants: INSTITUT D'INVESTIGACIONES BIOMÈDIQUES AUGUST PI I SUNYER
INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
UNIVERSITAT DE BARCELONA
HOSPITAL CLÍNIC DE BARCELONA
Inventors: DALMAU, Josep
GRAUS, Francesc
Title: DIAGNOSIS OF A NEUROLOGICAL DISEASE
Abstract:
The present invention concerns subject matter connected to or making use of lgLON5, lgLON5 fragments and variants of lgLON5 and lgLON5-fragments. In particular the present invention relates to a use of a polypeptide comprising one or more sequences of IgLON5, an lgLON5-fragment or a variant thereof for the diagnosis of a disease, in vitro methods for diagnosing such a disease, a polypeptide comprising one or more sequences of lgLON5, an lgLON5-fragment or a variant thereof or a nucleic acid encoding said polypeptide for use in the treatment of a disease, a pharmaceutical composition comprising such polypeptide, a method for treating such a disease, an autoantibody binding to IgLON5, an lgLON5-fragment or a variant thereof, a method for isolating such autoantibody, a medical or diagnostic device comprising such autoantibody or such polypeptide and a test kit for the diagnosis of a disease, which test kit comprises such autoantibody and/or such polypeptide.