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1. (WO2015118030) ANTIBODY-DRUG CONJUGATES AND IMMUNOTOXINS

Pub. No.:    WO/2015/118030    International Application No.:    PCT/EP2015/052341
Publication Date: Fri Aug 14 01:59:59 CEST 2015 International Filing Date: Thu Feb 05 00:59:59 CET 2015
IPC: A61K 47/48
C07K 16/30
C07K 14/42
Applicants: ONCOMATRYX BIOPHARMA, S.L.
Inventors: KONTERMANN, Roland
PFIZENMAIER, Klaus
FERRER, Cristina
FABRE, Myriam
SIMON, Laureano
Title: ANTIBODY-DRUG CONJUGATES AND IMMUNOTOXINS
Abstract:
The present invention relates to conjugates, in particular antibody-drug conjugates and immunotoxins, having the formula (I): A-(L-D)p or a pharmaceutically acceptable salts or solvates thereof, wherein A is an antibody that selectively binds FAP; L is a linker; D is a drug comprising a cytolysin or a Nigrin-b A-chain; and p is 1 to 10, and to use of such conjugates in the therapeutic treatment of tumors. Methods of producing such conjugates and components for use in such methods are disclosed.