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1. (WO2015117953) DIAGNOSIS OF CANCER BY DETECTING AUTO-ANTIBODIES AGAINST VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF)

Pub. No.:    WO/2015/117953    International Application No.:    PCT/EP2015/052184
Publication Date: Fri Aug 14 01:59:59 CEST 2015 International Filing Date: Wed Feb 04 00:59:59 CET 2015
IPC: G01N 33/564
G01N 33/574
G01N 33/74
Applicants: CELLTREND GMBH
Inventors: HEIDECKE, Harald
SCHULZE-FORSTER, Kai
Title: DIAGNOSIS OF CANCER BY DETECTING AUTO-ANTIBODIES AGAINST VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF)
Abstract:
The present invention relates to a method for diagnosis of a cancer, comprising the steps of (i) determining the level of antibodies against vascular endothelial growth factor (VEGF) in a sample from a subject to be diagnosed, (ii) comparing the determined level in the sample to a control level derived from subjects without cancer; wherein a decreased level in the sample from the subject to be diagnosed as compared to the control level is indicative for cancer in the subject. Furthermore, the invention relates to method of predicting response and outcome of a treatment of a cancer with an angiogenesis inhibitor.