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1. (WO2015117576) A SOLID FORM OF TAPENTADOL MALEATE AND A METHOD OF ITS PREPARATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/117576    International Application No.:    PCT/CZ2015/000011
Publication Date: 13.08.2015 International Filing Date: 30.01.2015
IPC:
C07C 215/54 (2006.01), C07C 57/145 (2006.01), A61K 31/135 (2006.01), A61P 29/00 (2006.01)
Applicants: ZENTIVA, K.S. [CZ/CZ]; U Kabelovny 130 102 37 Praha 10 (CZ)
Inventors: CERNY, Josef; (CZ).
DAMMER, Ondrej; (CZ).
PEKAREK, Tomas; (CZ).
CALTA, Pavel; (CZ)
Agent: JIROTKOVA, Ivana; Rott, Ruzicka & Guttmann Vinohradska 37, 120 00 Praha 2 (CZ)
Priority Data:
PV 2014-79 04.02.2014 CZ
Title (EN) A SOLID FORM OF TAPENTADOL MALEATE AND A METHOD OF ITS PREPARATION
(FR) FORME SOLIDE DU MALÉATE DE TAPENTADOL ET SON PROCÉDÉ DE PRÉPARATION
Abstract: front page image
(EN)The present solution relates to tapentadol maleate Form A of formula I, exhibiting the following characteristic reflections in an X-ray powder diffraction pattern, measured with the use of CuKa radiation: 10.7; 11.6; 16.0; 17.1; 20.4; 24.2 and 25.9 ± 0.2° 2-theta, the main onset temperature of 90.0°C when measured with the use of Differential Scanning Calorimetry (DSC), and the absorption peaks at 3217, 2971, 2874, 1705, 1619, 1587, 1534, 1484, 1351, 1250, 1188 a 1075 cm-1 in the IR spectrum.
(FR)La présente solution concerne la forme A du maléate de tapentadol de formule I, présentant les réflexions caractéristiques suivantes dans un profil de diffraction sur poudre des rayons X, mesurées en utilisant le rayonnement CuKa : 10,7 ; 11,6 ; 16,0 ; 17,1, 20,4, 24,2 et 25,9 ± 0,2° 2-thêta, la principale température d'apparition de 90,0 °C lorsqu'elle est mesurée par calorimétrie différentielle à compensation de puissance (ACD), et les pics d'absorption à 3217, 2971, 2874, 1705, 1619, 1587, 1534, 1484, 1351, 1250, 1188 a 1075 cm-1 dans le spectre IR.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)