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1. (WO2015117547) SUBSTITUTED PYRIMIDINES USEFUL AS EGFR-T790M KINASE INHIBITORS

Pub. No.:    WO/2015/117547    International Application No.:    PCT/CN2015/072179
Publication Date: Fri Aug 14 01:59:59 CEST 2015 International Filing Date: Wed Feb 04 00:59:59 CET 2015
IPC: C07D 403/12
A61K 31/16
A61P 35/04
Applicants: JIANGSU MEDOLUTION LIMITED
Inventors: ZHANG, Dawei
Title: SUBSTITUTED PYRIMIDINES USEFUL AS EGFR-T790M KINASE INHIBITORS
Abstract:
The present invention is directed to novel pyrimidines, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds and compositions of the present invention have protein kinases inhibitory activities and are expected to be useful for the treatment of protein kinases and/or mutants mediated diseases and conditions.