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1. (WO2015117538) NEW DAPAGLIFLOZIN CRYSTALLINE FORM AND PREPARATION METHOD THEREFOR

Pub. No.:    WO/2015/117538    International Application No.:    PCT/CN2015/071009
Publication Date: Fri Aug 14 01:59:59 CEST 2015 International Filing Date: Tue Jan 20 00:59:59 CET 2015
IPC: C07D 309/10
A61K 31/351
A61P 3/10
Applicants: JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD.
江苏豪森药业集团有限公司
Inventors: ZHU, Xifeng
朱希风
LI, Xiaobi
李孝壁
ZHANG, Tiancheng
张添程
YUAN, Fuping
袁阜平
Title: NEW DAPAGLIFLOZIN CRYSTALLINE FORM AND PREPARATION METHOD THEREFOR
Abstract:
The present invention relates to a new crystalline form of dapagliflozin represented by formula (I). The crystalline form has a characteristic absorption peak at about 4.318(20.45) in X-ray powder diffraction pattern shown by angle 2 theta and interplanar spacing (value d). It can be prepared by solving dapagliflozin into good organic solvents, adding poor solvents, agitating, crystallizing, filtering and drying. The new crystalline form of dapagliflozin of the present invention has the following superior features: good solubility, low hygroscopicity, high stability and good preparation reproducibility.