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1. (WO2015117241) SYSTEMS FOR OPTICAL IMAGING OF BIOLOGICAL TISSUES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2015/117241 International Application No.: PCT/CA2015/050085
Publication Date: 13.08.2015 International Filing Date: 05.02.2015
IPC:
A61B 5/00 (2006.01) ,A61B 6/00 (2006.01) ,G01N 21/01 (2006.01) ,G01N 21/64 (2006.01) ,G02B 27/10 (2006.01) ,G02B 27/30 (2006.01) ,G02B 6/024 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
6
Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
01
Arrangements or apparatus for facilitating the optical investigation
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
62
Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63
optically excited
64
Fluorescence; Phosphorescence
G PHYSICS
02
OPTICS
B
OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
27
Other optical systems; Other optical apparatus
10
Beam splitting or combining systems
G PHYSICS
02
OPTICS
B
OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
27
Other optical systems; Other optical apparatus
30
Collimators
G PHYSICS
02
OPTICS
B
OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
6
Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
02
Optical fibre with cladding
024
with polarisation-maintaining properties
Applicants:
BRITISH COLUMBIA CANCER AGENCY BRANCH [CA/CA]; 675 West 10th Avenue Vancouver, British Columbia V5Z 1L3, CA
Inventors:
LAM, Stephen; CA
LANE, Pierre; CA
LEE, Anthony; CA
PAHLEVANINEZHAD, Hamid; CA
MACAULAY, Calum; CA
Agent:
MANNING, Gavin N.; CA
Priority Data:
61/936,00305.02.2014US
62/004,60229.05.2014US
Title (EN) SYSTEMS FOR OPTICAL IMAGING OF BIOLOGICAL TISSUES
(FR) SYSTÈMES POUR IMAGERIE OPTIQUE DE TISSUS BIOLOGIQUES
Abstract:
(EN) A fiber-based polarization sensitive optical coherence tomography (PS-OCT) system uses a new polarization diversity detection (PDD) scheme and requires no active polarization modulating components. Retardation of the sample can be determined from amplitudes of arbitrarily-oriented x- and y-components of the reflected light. A hybrid custom 50/50 coupler with single-mode fiber inputs and polarization maintaining (PM) fiber outputs combines light from sample and reference arms of an interferometer. Another embodiment provides a system adapted to provide co-registered autofluorescence-optical coherence tomography (AF-OCT) imaging. AF excitation light is introduced and collected AF light is extracted at a fiber optic rotary joint (FORJ) equipped with an embedded dichroic mirror. A probe tip that uses a clad fiber to supply light to a focusing element provides enhanced OCT and AF performance.
(FR) L'invention concerne un système de tomographie en cohérence optique sensible à la polarisation (PS-OCT) à base de fibre, qui utilise une nouvelle technique de détection de diversité de polarisation (PDD) et ne nécessite aucun élément de modulation de polarisation active. Un retard optique de l'échantillon peut être déterminé à partir d'amplitudes d'éléments x et y orientés de façon arbitraire de la lumière réfléchie. Un coupleur 50/50 personnalisé hybride, ayant des entrées de fibres à mode unique et des sorties de fibres à maintien de polarisation (PM), combine la lumière de l'échantillon et des bras de référence d'un interféromètre. Un autre mode de réalisation concerne un système conçu pour permettre une imagerie par tomographie en cohérence optique à autofluorescence (AF-OCT) co-enregistrée. Une lumière d'excitation AF est introduite, et la lumière AF collectée est extraite au niveau d'un joint rotatif à fibre optique (FORJ) équipé d'un miroir dichroïque intégré. Une pointe de sonde, qui utilise une fibre de gaine pour fournir une lumière à un élément de mise au point, permet d'obtenir des performances OCT et AF améliorées.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20170196459