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1. WO2015117241 - SYSTEMS FOR OPTICAL IMAGING OF BIOLOGICAL TISSUES

Publication Number WO/2015/117241
Publication Date 13.08.2015
International Application No. PCT/CA2015/050085
International Filing Date 05.02.2015
IPC
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
A61B 6/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
6Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
G01N 21/01 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
01Arrangements or apparatus for facilitating the optical investigation
G01N 21/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
G02B 27/10 2006.01
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
27Optical systems or apparatus not provided for by any of the groups G02B1/-G02B26/119
10Beam splitting or combining systems
G02B 27/30 2006.01
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
27Optical systems or apparatus not provided for by any of the groups G02B1/-G02B26/119
30Collimators
CPC
A61B 5/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
A61B 5/0066
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0062Arrangements for scanning
0066Optical coherence imaging
A61B 5/0071
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0071by measuring fluorescence emission
A61B 5/0084
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0082adapted for particular medical purposes
0084for introduction into the body, e.g. by catheters
A61B 5/7235
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
72Signal processing specially adapted for physiological signals or for diagnostic purposes
7235Details of waveform analysis
G01B 2290/70
GPHYSICS
01MEASURING; TESTING
BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
2290Aspects of interferometers not specifically covered by any group under G01B9/02
70Using polarization in the interferometer
Applicants
  • BRITISH COLUMBIA CANCER AGENCY BRANCH [CA]/[CA]
Inventors
  • LAM, Stephen
  • LANE, Pierre
  • LEE, Anthony
  • PAHLEVANINEZHAD, Hamid
  • MACAULAY, Calum
Agents
  • MANNING, Gavin N.
Priority Data
61/936,00305.02.2014US
62/004,60229.05.2014US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYSTEMS FOR OPTICAL IMAGING OF BIOLOGICAL TISSUES
(FR) SYSTÈMES POUR IMAGERIE OPTIQUE DE TISSUS BIOLOGIQUES
Abstract
(EN)
A fiber-based polarization sensitive optical coherence tomography (PS-OCT) system uses a new polarization diversity detection (PDD) scheme and requires no active polarization modulating components. Retardation of the sample can be determined from amplitudes of arbitrarily-oriented x- and y-components of the reflected light. A hybrid custom 50/50 coupler with single-mode fiber inputs and polarization maintaining (PM) fiber outputs combines light from sample and reference arms of an interferometer. Another embodiment provides a system adapted to provide co-registered autofluorescence-optical coherence tomography (AF-OCT) imaging. AF excitation light is introduced and collected AF light is extracted at a fiber optic rotary joint (FORJ) equipped with an embedded dichroic mirror. A probe tip that uses a clad fiber to supply light to a focusing element provides enhanced OCT and AF performance.
(FR)
L'invention concerne un système de tomographie en cohérence optique sensible à la polarisation (PS-OCT) à base de fibre, qui utilise une nouvelle technique de détection de diversité de polarisation (PDD) et ne nécessite aucun élément de modulation de polarisation active. Un retard optique de l'échantillon peut être déterminé à partir d'amplitudes d'éléments x et y orientés de façon arbitraire de la lumière réfléchie. Un coupleur 50/50 personnalisé hybride, ayant des entrées de fibres à mode unique et des sorties de fibres à maintien de polarisation (PM), combine la lumière de l'échantillon et des bras de référence d'un interféromètre. Un autre mode de réalisation concerne un système conçu pour permettre une imagerie par tomographie en cohérence optique à autofluorescence (AF-OCT) co-enregistrée. Une lumière d'excitation AF est introduite, et la lumière AF collectée est extraite au niveau d'un joint rotatif à fibre optique (FORJ) équipé d'un miroir dichroïque intégré. Une pointe de sonde, qui utilise une fibre de gaine pour fournir une lumière à un élément de mise au point, permet d'obtenir des performances OCT et AF améliorées.
Also published as
Latest bibliographic data on file with the International Bureau