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1. (WO2015117121) P97 FUSION PROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/117121 International Application No.: PCT/US2015/014230
Publication Date: 06.08.2015 International Filing Date: 03.02.2015
IPC:
C07K 16/30 (2006.01) ,C07K 16/32 (2006.01) ,C07K 14/79 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
32
against translation products from oncogenes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
79
Transferrins, e.g. lactoferrins, ovotransferrins
Applicants: BIOASIS TECHNOLOGIES, INC.[CA/CA]; 130-10691 Shellbridge Way Richmond, British Columbia V6X 2W8, CA
Inventors: VITALIS, Timothy Z.; CA
GABATHULER, Reinhard; CA
Agent: ROGEL, Mark E.; US
Priority Data:
61/935,25303.02.2014US
Title (EN) P97 FUSION PROTEINS
(FR) PROTÉINES HYBRIDES P97
Abstract:
(EN) Provided are p97 (melanotransferrin)-trastuzumab fusion proteins and related methods of use thereof, for instance, to facilitate delivery of trastuzumab across the blood-brain barrier (BBB) and/or improve tissue penetration of the antibody in CNS and peripheral tissues, and thereby treat and/or diagnose HER2-positive cancers, including those of the central nervous system (CNS).
(FR) L'invention concerne des protéines hybrides p97 (mélanotransferrine)-trastuzumab, et des méthodes associées d'utilisation de celles-ci, par exemple pour faciliter le transport de trastuzumab à travers la barrière sang-cerveau (BSC) et/ou pour améliorer la pénétration d'un tissu par l'anticorps dans le SNC et les tissus périphériques, et ainsi traiter et/ou diagnostiquer des cancers HER2-positifs, notamment ceux du système nerveux central (SNC).
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)