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Machine translation
1. (WO2015117053) DIAMINOPYRIMIDINE BENZENESULFONE DERIVATIVES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/117053    International Application No.:    PCT/US2015/014039
Publication Date: 06.08.2015 International Filing Date: 02.02.2015
IPC:
C07D 403/14 (2006.01), A61K 31/506 (2006.01), A61K 31/5377 (2006.01)
Applicants: DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 450 Brookline Avenue Boston, MA 02215 (US)
Inventors: BRADNER, James, E.; (US).
QI, Jun; (US).
TANAKA, Minoru; (US)
Agent: BAKER, C., Hunter; (US)
Priority Data:
61/934,635 31.01.2014 US
Title (EN) DIAMINOPYRIMIDINE BENZENESULFONE DERIVATIVES AND USES THEREOF
(FR) DÉRIVÉS DE DIAMINOPYRIMIDINE BENZÈNESULFONE ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention provides compounds of Formula (II) (e.g., compounds of Formula (I)), and pharmaceutically compositions thereof. Compounds of Formula (II) are believed to be binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.
(FR)Cette invention concerne des composés de Formule (II) (p. ex., composés de Formula (I)), et des compositions pharmaceutiques les contenant. On pense que les composés de Formule (II) sont des liants de bromodomaines et/ou de protéines contenant des bromodomaines (p. ex., protéines à bromodomaines et domaine extraterminal (BET)). Cette invention concerne également des méthodes, des utilisations, et des kits utilisant lesdits composés et lesdites compositions pharmaceutiques pour inhiber l'activité (p. ex., l'activité accrue) des bromodomaines et/ou des protéines contenant des bromodomaines et pour traiter et/ou prévenir chez un sujet les maladies associées aux bromodomaines et/ou aux protéines contenant des bromodomaines (p.ex., maladies prolifératives, maladies cardiovasculaires, infections virales, maladies fibrotiques, maladies endocriniennes, et empoisonnement par rayonnement). Les composés, les compositions pharmaceutiques, et les kits selon l'invention sont également utiles pour la contraception masculine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)