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1. (WO2015117048) TREATMENT OF CIRCADIAN RHYTHM DISORDERS

Pub. No.:    WO/2015/117048    International Application No.:    PCT/US2015/014014
Publication Date: Fri Aug 07 01:59:59 CEST 2015 International Filing Date: Sun Feb 01 00:59:59 CET 2015
IPC: A61K 31/165
A61K 31/195
A61K 31/343
Applicants: VANDA PHARMACEUTICALS INC.
Inventors: DRESSMAN, Marlene Michelle
LICAMELE, Louis William
POLYMEROPOULOS, Mihael H.
Title: TREATMENT OF CIRCADIAN RHYTHM DISORDERS
Abstract:
Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm. In some embodiments, the invention relates to a method of treating a patient suffering from Non-24-Hour Sleep-Wake Disorder that comprises deferring or suspending treatment with tasimelteon while the patient is being treated with an inducer of CYP3A4.