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1. (WO2015116947) ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/116947    International Application No.:    PCT/US2015/013808
Publication Date: 06.08.2015 International Filing Date: 30.01.2015
IPC:
C07D 405/14 (2006.01)
Applicants: UNIVERSITY OF CONNECTICUT [US/US]; 263 Farmington Avenue Farmington, Connecticut 06030 (US)
Inventors: HADDEN, Matthew Kyle; (US).
BANERJEE, Upasana; (US)
Agent: LECUYER, Karen A.; (US)
Priority Data:
61/934,714 01.02.2014 US
Title (EN) ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF
(FR) DÉRIVÉS D'ITRACONAZOLE ET LEURS MÉTHODES D'UTILISATION
Abstract: front page image
(EN)Disclosed herein are analogues of itraconazole that are both angiogenesis and hedgehog signaling pathway inhibitors. The compounds are expected to be useful in the treatment of cancer, particularly cancers that are dependent upon the hedgehog signaling pathway such as basal cell carcinoma and medulloblastoma.
(FR)L'invention concerne des analogues d'itraconazole qui sont des inhibiteurs de la voie de signalisation Hedgehog et de l'angiogenèse. Les composés sont censés être utiles dans le traitement du cancer, en particulier de cancers qui dépendent de la voie de signalisation Hedgehog tel que le carcinome basocellulaire et le médulloblastome.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)