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1. (WO2015116923) ISOINDOLINE COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/116923 International Application No.: PCT/US2015/013754
Publication Date: 06.08.2015 International Filing Date: 30.01.2015
IPC:
A61K 31/404 (2006.01) ,A61K 31/405 (2006.01) ,A61P 25/28 (2006.01) ,A61P 25/00 (2006.01)
Applicants: COGNITION THERAPEUTICS, INC.[US/US]; 2403 Sidney Street Suite 261 Pittsburgh, PA 15203, US
Inventors: RISHTON, Gilbert; US
CATALANO, Susan, M.; US
LOOK, Gary, C.; US
Agent: GOGORIS, Adda C.; US
Priority Data:
61/934,52831.01.2014US
Title (EN) ISOINDOLINE COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
(FR) COMPOSITIONS ISOINDOLINE ET MÉTHODES DE TRAITEMENT D'UNE MALADIE NEURODÉGÉNÉRATIVE
Abstract:
(EN) Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta- associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.
(FR) L'invention concerne des composés isoindoline antagonistes du récepteur sigma-2, des compositions pharmaceutiques comprenant ces composés, et des méthodes pour inhiber la perte synaptique ou le dysfonctionnement synaptique associés à l'abêta dans des cellules neuronales, pour moduler un changement de traitement de membrane associé à l'abêta dans des cellules neuronales, et pour traiter le déclin cognitif associé à une pathologie abêta.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)