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Machine translation
1. (WO2015116852) METHODS FOR TREATING RHEUMATOID ARTHRITIS BY ADMINISTERING AN IL-6R ANTIBODY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/116852    International Application No.:    PCT/US2015/013588
Publication Date: 06.08.2015 International Filing Date: 29.01.2015
IPC:
A61K 39/395 (2006.01)
Applicants: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road Tarrytown, NY 10591 (US).
SANOFI BIOTECHNOLOGY [FR/FR]; 54 rue La Boétie F-75008 Paris (FR)
Inventors: BOYAPATI, Anita; (US).
HAMILTON, Jennifer, Davidson; (US).
MSIHID, Jérôme; (FR).
COUSIN, Emmanuelle; (FR).
CAI, Ling; (FR).
FIORE, Stefano; (US).
VAN ADELSBERG, Janet; (US)
Agent: COWLES, Cristin, H.; (US)
Priority Data:
62/073,638 31.10.2014 US
61/986,933 01.05.2014 US
61/933,156 29.01.2014 US
62/011,675 13.06.2014 US
14306771.8 05.11.2014 EP
Title (EN) METHODS FOR TREATING RHEUMATOID ARTHRITIS BY ADMINISTERING AN IL-6R ANTIBODY
(FR) MÉTHODES DE TRAITEMENT DE LA POLYARTHRITE RHUMATOÏDE PAR L'ADMINISTRATION D'UN ANTICORPS ANTI IL-6R
Abstract: front page image
(EN)The present invention provides methods for treating rheumatoid arthritis (RA). Also provided are methods for improving one or more RA-associated parameter(s), methods for decreasing the level of at least one RA-associated biomarker in a subject in need thereof, and methods for treating RA according to the expression levels of one or more RA-associated biomarkers. The methods of the present invention comprise administering to a subject in need thereof a pharmaceutical composition comprising an interleukin-6 receptor (IL-6R) antagonist such as an anti-IL-6R antibody.
(FR)La présente invention concerne des procédés de traitement de la polyarthrite rhumatoïde (PR). L'invention concerne également des procédés d'amélioration d'un ou plusieurs paramètres associés à la PR, des méthodes de réduction du niveau d'au moins un biomarqueur associé à la PR chez un sujet en ayant besoin, et des méthodes de traitement de la PR selon les niveaux d'expression d'un ou de plusieurs biomarqueurs associés à la PR. Les méthodes de la présente invention comprennent l'administration à un sujet en ayant besoin d'une composition pharmaceutique comprenant un antagoniste du récepteur de l'interleukine 6 (IL-6R) tel qu'un anticorps anti-IL-6R.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)