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1. (WO2015116846) MODULATION OF TISSUE TRANSGLUTAMINASE ACTIVATION IN DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/116846    International Application No.:    PCT/US2015/013576
Publication Date: 06.08.2015 International Filing Date: 29.01.2015
IPC:
C07D 413/12 (2006.01), C07D 261/04 (2006.01), A61K 31/42 (2006.01)
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; Office of the General Counsel Building 170, 3rd Floor, Main Quad P.O. Box 20386 Stanford, CA 94305-2038 (US)
Inventors: KHOSLA, Chaitan; (US).
DIRAIMONDO, Thomas; (US).
KLOECK, Cornelius; (DE)
Agent: SHERWOOD, Pamela J.; (US)
Priority Data:
61/933,711 30.01.2014 US
Title (EN) MODULATION OF TISSUE TRANSGLUTAMINASE ACTIVATION IN DISEASE
(FR) MODULATION DE L'ACTIVATION DE LA TRANSGLUTAMINASE TISSULAIRE DANS UNE MALADIE
Abstract: front page image
(EN)Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2); which methods can include inhibiting the activity of TG2 associated with inflammatory disorders, which disorders may include, without limitation, sepsis, ischemic reperfusion injury, renal fibrosis, and the like.
(FR)L'invention concerne des compositions et des méthodes permettant de moduler l'activation physiologique de la transglutaminase tissulaire (TG2). Ces méthodes peuvent consister à inhiber l'activité de TG2 associée à des troubles inflammatoires, qui peuvent comprendre, mais sans s'y limiter, la sepsie, les blessures de reperfusion ischémique, la fibrose rénale, et analogues.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)