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1. (WO2015116740) METHODS AND COMPOSITIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/116740    International Application No.:    PCT/US2015/013387
Publication Date: 06.08.2015 International Filing Date: 28.01.2015
IPC:
A61P 1/16 (2006.01), A61K 35/12 (2015.01), A61K 39/395 (2006.01)
Applicants: BUCK INSTITUTE FOR RESEARCH ON AGING [US/US]; 8001 Redwood Boulevard Novato, California 94945 (US).
UNITY BIOTECHNOLOGY, INC. [US/US]; 1700 Owens Street, Suite 535 San Francisco, California 94158 (US).
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH [US/US]; 200 First Street Southwest Rochester, Minnesota 55905 (US).
THE JOHNS HOPKINS UNIVERSITY [US/US]; 3400 N. Charles Street Baltimore, Maryland 21218 (US)
Inventors: LABERGE, Remi-Martin; (US).
CAMPISI, Judith; (US).
DAVALOS, Albert; (US).
DEMARIA, Marco; (US).
DAVID, Nathaniel; (US).
VASSEROT, Alain, Philippe; (US).
BAKER, Darren, J.; (US).
CHILDS, Bennett, G.; (US).
KIRKLAND, James, L.; (US).
TCHKONIA, Tamar; (US).
VAN DEURSEN, Jan, M.A.; (US).
ZHU, Yi; (US).
ELISSEEFF, Jennifer; (US).
KIM, Chaekyu; (US).
JEON, Okhee; (US)
Agent: MCNAMARA, Laurie; (US)
Priority Data:
61/932,704 28.01.2014 US
61/932,711 28.01.2014 US
61/979,911 15.04.2014 US
62/002,709 23.05.2014 US
62/042,708 27.08.2014 US
62/044,664 02.09.2014 US
62/057,820 30.09.2014 US
62/057,825 30.09.2014 US
62/057,828 30.09.2014 US
62/061,627 08.10.2014 US
62/061,629 08.10.2014 US
Title (EN) METHODS AND COMPOSITIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS
(FR) PROCÉDÉS ET COMPOSITIONS PERMETTANT DE TUER LES CELLULES SÉNESCENTES ET DE TRAITER LES MALADIES ET LES TROUBLES ASSOCIÉS À LA SÉNESCENCE
Abstract: front page image
(EN)Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
(FR)L'invention concerne des procédés permettant de sélectivement tuer les cellules sénescentes et de traiter les maladies et les troubles associés à la sénescence par l'administration d'un agent sénolytique. Les maladies et troubles associés à la sénescence et pouvant être traités par les procédés utilisant les agents sénolytiques de l'invention comprennent les maladies et troubles cardiovasculaires associés à ou causés par l'artériosclérose, par exemple l'athérosclérose; la fibrose pulmonaire idiopathique; la bronchopneumopathie chronique obstructive; l'arthrose; les maladies et troubles ophtalmiques associés à la sénescence; et les maladies et troubles dermatologiques associés à la sénescence.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)