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1. (WO2015116735) METHODS AND COMBINATIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/116735    International Application No.:    PCT/US2015/013376
Publication Date: 06.08.2015 International Filing Date: 28.01.2015
IPC:
A61K 45/06 (2006.01)
Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH [US/US]; 200 First Street Southwest Rochester, Minnesota 55905 (US)
Inventors: KIRKLAND, James, L.; (US).
TCHKONIA, Tamar; (US).
ZHU, Yi; (US).
PALMER, Allyson, K.; (US).
LeBRASSEUR, Nathan, K.; (US).
MILLER, Jordan, D.; (US).
XU, Ming; (US)
Agent: MCNAMARA, Laurie; (US)
Priority Data:
61/932,711 28.01.2014 US
61/932,704 28.01.2014 US
Title (EN) METHODS AND COMBINATIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS
(FR) PROCÉDÉS ET COMBINAISONS POUR TUER DES CELLULES SÉNESCENTES ET TRAITER DES MALADIES ET TROUBLES ASSOCIÉS À UNE SÉNESCENCE
Abstract: front page image
(EN)Provided herein are methods and uses for treatment or prophylaxis of a senescent cell associated disease or disorder by administering a senolytic combination comprising dasatinib and quercetin or an analog thereof to a subject in need thereof. In certain embodiments, the senescent cell associated disease or disorder is a cardiovascular disease or disorder, inflammatory disease or disorder, a pulmonary disease or disorder, a neurological disease or disorder, or a metabolic disease or disorder.
(FR)L'invention concerne des procédés et des utilisations pour le traitement ou la prophylaxie d'une maladie ou trouble associé à une cellule sénescente par administration, à un sujet en ayant besoin, d'une combinaison sénolytique comprenant du dasatinib et de la quercétine ou un analogue de ces derniers. Dans certains modes de réalisation, la maladie ou trouble associé à une cellule sénescente est une maladie ou trouble cardiovasculaire, une maladie ou trouble inflammatoire, une maladie ou trouble pulmonaire, une maladie ou trouble neurologique, ou une maladie ou trouble métabolique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)