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1. (WO2015116729) ANTI-CD37 ANTIBODY AND ANTI-CD20 ANTIBODY COMBINATION THERAPY FOR TREATMENT OF B-CELL MALIGNANCIES AND DISORDERS

Pub. No.:    WO/2015/116729    International Application No.:    PCT/US2015/013367
Publication Date: Fri Aug 07 01:59:59 CEST 2015 International Filing Date: Thu Jan 29 00:59:59 CET 2015
IPC: A61K 39/395
C07K 16/00
Applicants: EMERGENT PRODUCT DEVELOPMENT SEATTLE, LLC
Inventors: STROMATT, Scott
GORDON, Brian
Title: ANTI-CD37 ANTIBODY AND ANTI-CD20 ANTIBODY COMBINATION THERAPY FOR TREATMENT OF B-CELL MALIGNANCIES AND DISORDERS
Abstract:
The present invention provides methods of treating a patient with a B-cell malignancy or disorder comprising administering an anti-CD37 antibody or antibody fragment in combination with an anti-CD20 antibody or antibody fragment. In one embodiment, the invention provides methods for B-cell reduction comprising contacting B-cells with an anti-CD37 antibody or antibody fragment and an anti-CD20 antibody or antibody fragment. The invention includes compositions and kits comprising anti-CD37 antibody and antibody fragments for use in combination with an anti-CD20 antibody or antibody fragment. The methods and compositions of the invention may further include a BCR antagonist such as a SYK inhibitor, a BTK inhibitor, a PI3K inhibitor, or a CXCR4 antagonist.