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1. (WO2015116663) HETEROARYL AMIDES AS INHIBITORS OF PROTEIN AGGREGATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/116663    International Application No.:    PCT/US2015/013263
Publication Date: 06.08.2015 International Filing Date: 28.01.2015
Chapter 2 Demand Filed:    25.11.2015    
IPC:
C07D 417/14 (2006.01), A61K 31/4045 (2006.01), A61P 25/28 (2006.01)
Applicants: NEUROPORE THERAPIES, INC. [US/US]; 10835 Road to the Cure, Suite 210 San Diego, CA 92121 (US)
Inventors: STOCKING, Emily, M.; (US).
WRASIDLO, Wolfgang; (US)
Agent: MULLEN, James, J., III; (US)
Priority Data:
61/933,246 29.01.2014 US
62/078,895 12.11.2014 US
Title (EN) HETEROARYL AMIDES AS INHIBITORS OF PROTEIN AGGREGATION
(FR) AMIDES HÉTÉROARYLES COMME INHIBITEURS DE L'AGRÉGATION PROTÉIQUE
Abstract: front page image
(EN)The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.
(FR)La présente invention concerne certains composés d'amide hétéroaryles, des compositions pharmaceutiques les contenant et des procédés d'utilisation associés, notamment des procédés permettant de prévenir, inverser, ralentir et inhiber l'agrégation protéique, et des procédés permettant de traiter des maladies qui sont associées à l'agrégation protéique, notamment les maladies neurodégénératives telles que la maladie de Parkinson, la maladie d'Alzheimer, la maladie du corps de Lewy, la maladie de Parkinson avec démence, la démence fronto-temporale, la maladie de Huntington, la sclérose latérale amyotrophique et l'atrophie multisystématisée, et le cancer et le mélanome.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)