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1. (WO2015116530) MUTATIONS DEFINE CLINICAL SUBGROUPS OF GLIOMAS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/116530    International Application No.:    PCT/US2015/012888
Publication Date: 06.08.2015 International Filing Date: 26.01.2015
IPC:
C12M 1/34 (2006.01), C12Q 1/68 (2006.01)
Applicants: DUKE UNIVERSITY [US/US]; 2812 Erwin Road Suite 306 BOX 90083 Durham, North Carolina 27705 (US)
Inventors: YAN, Hai; (US).
BIGNER, Darell; (US).
KILLELA, Patrick; (US).
REITMAN, Zachary; (US)
Agent: KAGAN, Sarah A.; (US)
Priority Data:
61/932,291 28.01.2014 US
Title (EN) MUTATIONS DEFINE CLINICAL SUBGROUPS OF GLIOMAS
(FR) MUTATIONS DÉFINISSANT DES SOUS GROUPES CLINIQUES DE GLIOMES
Abstract: front page image
(EN)Genetic signatures capable of distinguishing among several types of gliomas provide clinically relevant information that can serve as an adjunct to histopathological diagnosis. For example, mutations in the TERT promoter occurred in 74.2% of glioblastomas (GBM), but occurred in a minority of Grade II-III astrocytomas (18.2%). In contrast, IDH1/2 mutations were observed in 78.4% of Grade II-III astrocytomas, but were uncommon in primary GBM. The genetic signatures permit the stratification of the glioma patients into distinct cohorts.
(FR)L'invention concerne des signatures génétiques aptes à distinguer plusieurs types de gliomes procurant des informations cliniquement pertinentes qui peuvent servir d'auxiliaire à un diagnostic histopathologique. Par exemple, des mutations dans le promoteur TERT sont apparues dans 74,2 % des glioblastomes (GBM), mais sont apparues dans une minorité d'astrocytomes de grade II-III (18,2 %). En revanche, des mutations IDH1/2 ont été observées dans 78,4 % des astrocytomes de grade II-III, mais étaient plus rares dans les GBM primaires. Les signatures génétiques permettent la stratification des patients atteints de gliome en cohortes distinctes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)