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1. (WO2015115673) FUSED IMIDAZOLE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/115673    International Application No.:    PCT/JP2015/053314
Publication Date: 06.08.2015 International Filing Date: 30.01.2015
IPC:
C07D 401/12 (2006.01), A61K 31/4439 (2006.01), A61K 31/4709 (2006.01), A61K 31/517 (2006.01), A61K 31/519 (2006.01), A61K 31/538 (2006.01), A61K 31/5383 (2006.01), A61P 25/00 (2006.01), A61P 25/06 (2006.01), A61P 25/08 (2006.01), A61P 25/14 (2006.01), A61P 25/16 (2006.01), A61P 25/18 (2006.01), A61P 25/20 (2006.01), A61P 25/22 (2006.01), A61P 25/24 (2006.01), A61P 25/28 (2006.01), A61P 25/32 (2006.01), C07D 401/14 (2006.01), C07D 403/12 (2006.01), C07D 413/12 (2006.01), C07D 413/14 (2006.01), C07D 471/04 (2006.01), C07D 473/32 (2006.01), C07D 498/04 (2006.01), C07D 519/00 (2006.01)
Applicants: ONO PHARMACEUTICAL CO., LTD. [JP/JP]; 1-5, Doshomachi 2-chome, Chuo-ku, Osaka-shi, Osaka 5418526 (JP)
Inventors: SAITO, Tetsuji; (JP).
HIGASHINO, Masato; (JP).
KAWAHARADA, Soichi; (JP).
LEWIS, Arwel; (GB).
CHAMBERS, Mark Stuart; (GB).
RAE, Alastair; (GB).
HIRST, Kim Louise; (GB).
HARTLEY, Charles David; (GB)
Agent: AOKI, Atsushi; (JP)
Priority Data:
2014-017798 31.01.2014 JP
Title (EN) FUSED IMIDAZOLE COMPOUNDS
(FR) COMPOSÉS D'IMIDAZOLE CONDENSÉS
Abstract: front page image
(EN)The present invention provides compounds represented by formula (I), pharmaceutically acceptable salts thereof, N-oxides thereof, solvates thereof or prodrugs thereof (wherein the characters are as defined in the description). The compounds represented by formula (I) have affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 (GABAA α5) and act as GABAA α5 negative allosteric modulators (GABAA α5 NAM), so that they are useful in the prevention and/or treatment of diseases which are related to the GABAA α5 such as Alzheimer's disease.
(FR)La présente invention concerne des composés représentés par la formule (I), leurs sels, N-oxydes, solvats ou promédicaments pharmaceutiquement acceptables (où les caractères sont tels que définis dans la description). Les composés représentés par la formule (I) présentent une affinité et une sélectivité pour la sous-unité alpha 5 du récepteur de l'acide gamma-aminobutyrique A (GABAA alfa5) et agissent comme modulateurs allostériques négatifs de GABAA alfa5 (GABAA alfa5 NAM), de telle sorte qu'ils sont utiles dans la prévention et/ou le traitement de maladies qui sont liées à GABAA alfa5 comme la maladie d'Alzheimer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)