WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Options
Query Language
Stem
Sort by:
List Length
1. (WO2015114817) THERAPEUTIC OR PROPHYLACTIC AGENT FOR DISEASES ASSOCIATED WITH BONE RESORPTION WHICH CONTAINS CYCLIC PEPTIDE AS ACTIVE INGREDIENT
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/114817 International Application No.: PCT/JP2014/052335
Publication Date: 06.08.2015 International Filing Date: 31.01.2014
IPC:
A61K 38/00 (2006.01) ,C07K 7/64 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
64
Cyclic peptides containing only normal peptide links
Applicants: SUNTORY HOLDINGS LIMITED[JP/JP]; 1-40, Dojimahama 2-chome, Kita-ku, Osaka-shi, Osaka 5308203, JP
HOSHI UNIVERSITY[JP/JP]; 2-4-41, Ebara, Shinagawa-ku, Tokyo 1428501, JP
Inventors: MORITA, Hiroshi; JP
KANEDA, Toshio; JP
Agent: ONO, Shinjiro; YUASA AND HARA, Section 206, New Ohtemachi Bldg., 2-1, Ohtemachi 2-chome, Chiyoda-ku, Tokyo 1000004, JP
Priority Data:
Title (EN) THERAPEUTIC OR PROPHYLACTIC AGENT FOR DISEASES ASSOCIATED WITH BONE RESORPTION WHICH CONTAINS CYCLIC PEPTIDE AS ACTIVE INGREDIENT
(FR) AGENT THÉRAPEUTIQUE OU PROPHYLACTIQUE DESTINÉ AUX MALADIES ASSOCIÉES À LA RÉSORPTION OSSEUSE QUI CONTIENT UN PEPTIDE CYCLIQUE COMME PRINCIPE ACTIF
(JA) 環状ペプチドを有効成分とする骨吸収関連疾患の治療又は予防剤
Abstract:
(EN) The present invention addresses the problem of providing an osteoclast differentiation inhibitor which is derived from a naturally occurring material, can be administered for a long period and is highly effective. The present invention also addresses the problem of providing a prophylactic or therapeutic agent for diseases associated with bone resorption, which is derived from a naturally occurring material, can be administered for a long period and is highly effective. It is found that a cyclic peptide derived from a plant Linum usitatissimum can inhibit a RANKL signal which is required for the differentiation of an osteoclast, and therefore can inhibit the differentiation of a bone-marrow-derived myeloid cell into an osteoclast. By using the cyclic peptide as an active ingredient, it becomes possible to provide a food, a beverage or a medicine for preventing or treating a condition or disease associated with bone resorption, such as osteoporosis.
(FR) La présente invention vise à procurer un inhibiteur de la différentiation des ostéoclastes qui est dérivé d'une matière d'origine naturelle, peut être administré sur une longue période et est très efficace. La présente invention vise également à procurer un agent prophylactique ou thérapeutique pour les maladies associées à la résorption osseuse, qui est dérivé d'une matière d'origine naturelle, peut être administré sur une longue période et est très efficace. L'invention concerne un peptide cyclique dérivé d'une plante Linum usitatissimum pouvant inhiber un signal RANKL requis pour la différentiation d'un ostéoclaste, et pouvant donc inhiber la différentiation d'une cellule myéloïde dérivée de moelle osseuse en un ostéoclaste. Grâce à l'utilisation du peptide cyclique comme principe actif, il devient possible de procurer un aliment, une boisson ou un médicament destiné à prévenir ou traiter une affection ou une maladie associée à la résorption osseuse, telle que l'ostéoporose.
(JA)  本発明の目的は、天然物起源で長期投与であり、効果の高い破骨細胞分化抑制剤を提供することである。また天然物起源で長期投与であり、効果の高い骨吸収関連疾患の予防および治療剤を提供することである。 アマ由来の環状ペプチドが破骨細胞の分化に必要なRANKLシグナルを抑制し、骨髄ミエロイド系細胞から破骨細胞への分化を抑制することを見出した。それらの環状ペプチドを有効成分とすることで、骨粗鬆症などの骨吸収に関連した状態や疾患の予防や治療を目的とした飲食品や医薬品を提供することができる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)