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1. (WO2015114638) USE OF CASEIN KINASE I INHIBITORS FOR DEPLETING STEM CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/114638    International Application No.:    PCT/IL2015/050118
Publication Date: 06.08.2015 International Filing Date: 03.02.2015
IPC:
A61K 31/00 (2006.01), A61K 31/506 (2006.01), A61K 35/12 (2015.01), C12Q 1/00 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01)
Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. [IL/IL]; Hi Tech Park, The Edmond J. Safra Campus The Hebrew University of Jerusalem Givat Ram P.O. Box 39135 9139002 Jerusalem (IL)
Inventors: BEN-NERIAH, Yinon; (IL).
MINZEL, Waleed; (IL).
BRACHYA, Guy; (IL)
Agent: G.E. EHRLICH (1995) LTD.; 11 Menachem Begin Road 5268104 Ramat Gan (IL)
Priority Data:
61/934,954 03.02.2014 US
Title (EN) USE OF CASEIN KINASE I INHIBITORS FOR DEPLETING STEM CELLS
(FR) MÉTHODE D'ÉLIMINATION DE CELLULES SOUCHES
Abstract: front page image
(EN)A method of treating cancer in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of a Casein kinase I alpha (CKIalpha) inhibitor, wherein the cancer is not associated with an Adenomatous polyposis coli (APC) mutation. Additional uses of CKI inhibitors are also disclosed.
(FR)L'invention concerne une méthode de traitement du cancer chez un sujet. Le procédé comprend l'administration au sujet d'une quantité thérapeutiquement efficace d'une caséine kinase I alpha (CKIalpha), le cancer n'étant pas associé à une mutation de polypose adénomateuse colique (APC). L'invention concerne également des utilisations supplémentaires d'inhibiteurs de CKI.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)
Licensing availability request The applicant has requested the International Bureau to indicate the availability for licensing purposes of the invention(s) claimed in this international application