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Machine translation
1. (WO2015114320) ASSISTED PARTICLE SIZE REDUCTION PROCESS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/114320    International Application No.:    PCT/GB2015/050186
Publication Date: 06.08.2015 International Filing Date: 27.01.2015
Chapter 2 Demand Filed:    27.11.2015    
IPC:
A61K 9/00 (2006.01), A61K 9/14 (2006.01), A61K 31/439 (2006.01), A61K 31/52 (2006.01), A61K 31/56 (2006.01)
Applicants: HOVIONE INTERNATIONAL LTD [CN/CN]; Aubin House, 11th Floor 171-172 Gloucester Road Wanchai Hong Kong (CN).
TURNER, Craig [GB/GB]; (GB) (MW only)
Inventors: COSTA, Eunice; (PT).
TEMTEM, Márcio; (PT).
SOBRAL, Luis; (PT).
CACELA, Constança; (PT).
VILLAX, Peter; (PT)
Agent: A.A. THORNTON & CO.; 10 Old Bailey London EC4M 7NG (GB)
Priority Data:
107433 28.01.2014 PT
Title (EN) ASSISTED PARTICLE SIZE REDUCTION PROCESS
(FR) PROCÉDÉ DE RÉDUCTION DE TAILLE DE PARTICULE ASSISTÉE
Abstract: front page image
(EN)A new scalable process to control the particle size and the particle size distribution, comprising5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents; (ii) particle size reduction of the suspension; (iii) aging; (iv)stopping the aging by solvent removal; and (v) optionally, a step of isolating the processed ingredients in the form of powder.
(FR)La présente invention concerne un nouveau procédé évolutif pour contrôler la taille de particule et la granulométrie, comprenant 5 étapes : (i) préparation d’une suspension dans un mélange de solvants dans laquelle la substance active et/ou l’excipient est partiellement soluble dans un des solvants ; (ii) réduction de taille de particule de la suspension ; (iii) maturation ; (iv) arrêt de la maturation par élimination des solvants ; et (v) facultativement, une étape d’isolement des composants traités sous la forme de poudre.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)