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1. (WO2015114166) TARGETED DRUG CONJUGATES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/114166    International Application No.:    PCT/EP2015/052205
Publication Date: 06.08.2015 International Filing Date: 03.02.2015
IPC:
A61K 47/48 (2006.01), A61P 35/00 (2006.01)
Applicants: PHILOCHEM AG [CH/CH]; Libernstrasse 3 CH-8112 Otelfingen (CH)
Inventors: CASI, Giulio; (CH).
PRETTO, Francesca; (CH)
Agent: MASCHIO, Antonio; (GB)
Priority Data:
1401818.8 03.02.2014 GB
1407533.7 29.04.2014 GB
1419996.2 10.11.2014 GB
1422399.4 16.12.2014 GB
Title (EN) TARGETED DRUG CONJUGATES
(FR) CONJUGUÉS MÉDICAMENTEUX CIBLÉS
Abstract: front page image
(EN)A targeted therapeutic agent comprising a compound of formula: B - L - D wherein: B is a non-internalizing binding moiety specific for a cancer associated protein; D is a cytotoxic drug moiety; and L is a linker group that undergoes cleavage in vivo for releasing said drug moiety in an active form. The binding moiety is a ligand for the cancer associated protein whereby drawbacks associated with the use of internalizing ligands are avoided.
(FR)Cette invention concerne un agent thérapeutique ciblé comprenant un composé de formule : B-L-D où : B est un fragment de liaison de type non-internalisation spécifique d'une protéine associée au cancer; D est un fragment médicament cytotoxique; et L est un groupe lieur qui subit un clivage in vivo pour libérer ledit fragment médicament sous une forme active. Le fragment de liaison est un ligand pour protéine associée au cancer qui élimine les inconvénients associés à l'utilisation de ligands d'internalisation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)