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1. (WO2015113986) COMPOSITION COMPRISING EPA AND DHA ETHYLESTER FOR PARENTERAL ADMINISTRATION

Pub. No.:    WO/2015/113986    International Application No.:    PCT/EP2015/051656
Publication Date: Fri Aug 07 01:59:59 CEST 2015 International Filing Date: Thu Jan 29 00:59:59 CET 2015
IPC: A61K 9/00
A61K 47/12
A61K 47/24
A61K 9/107
Applicants: FRESENIUS KABI DEUTSCHLAND GMBH
Inventors: BRITO DE LA FUENTE, Edmundo
GALLEGOS-MONTES, Crispulo
QUINCHIA-BUSTAMENTE, Lida A.
Title: COMPOSITION COMPRISING EPA AND DHA ETHYLESTER FOR PARENTERAL ADMINISTRATION
Abstract:
The present invention relates to a composition for parenteral administration comprising an aqueous phase and 5 to 30 % by weight of an oil phase, based on the total weight of the composition, wherein the oil phase comprises omega-3 fatty acid ethylesters selected from the group consisting of eicosapentaenoic acid ethylester, docosahexaenoic acid ethylester and mixtures thereof, and wherein the composition further comprises at least one anionic surfactant and at least one amphoteric surfactant, and wherein the composition comprises less than 0.05 % by weight of oleic acid, based on the total weight of the composition. Further, the present invention relates to a method for preparing such a composition as well as to such a composition for use as a medicament, in particular for use in treating stroke, sepsis, Alzheimer's disease or cancer. Furthermore, the present invention relates to a method for treating stroke, sepsis, Alzheimer's disease or cancer comprising parenterally administering such a composition to a patient in need thereof and to a method of providing parenteral nutrition to a patient suffering from at least one disease selected from stroke, sepsis, Alzheimer's disease or cancer, the method comprising administering such a composition to the patient.