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1. (WO2015113569) BIOSYNTHESIS OF FORSKOLIN AND RELATED COMPOUNDS

Pub. No.:    WO/2015/113569    International Application No.:    PCT/DK2015/050020
Publication Date: Fri Aug 07 01:59:59 CEST 2015 International Filing Date: Sat Jan 31 00:59:59 CET 2015
IPC: C12P 5/00
C12P 17/06
C12N 9/02
Applicants: UNIVERSITY OF COPENHAGEN
DANMARKS TEKNISKE UNIVERSITET
EVOLVA SA
Inventors: HAMBERGER, Björn
MØLLER, Birger Lindberg
PATERAKI, Eirini
ANDERSEN-RANBERG, Johan
JENSEN, Niels Bjerg
Title: BIOSYNTHESIS OF FORSKOLIN AND RELATED COMPOUNDS
Abstract:
The invention described materials and methods for producing oxidised 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R- MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.