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1. (WO2015113521) DEUTERATED QUINAZOLINONE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/113521    International Application No.:    PCT/CN2015/071996
Publication Date: 06.08.2015 International Filing Date: 30.01.2015
IPC:
C07D 487/04 (2006.01), C07D 473/34 (2006.01), A61K 31/52 (2006.01), A61P 3/00 (2006.01), A61P 9/00 (2006.01), A61P 29/00 (2006.01), A61P 31/00 (2006.01), A61P 35/00 (2006.01), A61P 37/02 (2006.01)
Applicants: SUZHOU ZELGEN BIOPHARMACEUTICALS CO., LTD. [CN/CN]; No. 209, Chenfeng Road Kunshan, Jiangsu 215300 (CN)
Inventors: LV, Binhua; (CN).
LI, Chengwei; (CN)
Agent: XU & PARTNERS, LLC.; Room No.106, Building No.1, Universal High-Tech Plaza 958 Zhen Bei Road, Putuo Shanghai 200333 (CN)
Priority Data:
201410044620.5 30.01.2014 CN
201410058184.7 20.02.2014 CN
Title (EN) DEUTERATED QUINAZOLINONE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
(FR) COMPOSÉ DE QUINAZOLINONE DEUTÉRÉ ET COMPOSITION PHARMACEUTIQUE LE COMPRENANT
(ZH) 氘代喹唑啉酮化合物以及包含该化合物的药物组合物
Abstract: front page image
(EN)The present invention relates to a deuterated quinazolinone compound and pharmaceutical composition comprising same. Particularly, disclosed are a deuterated quinazolinone compound and pharmaceutical composition comprising the compound, or crystal form, pharmaceutically acceptable salt, hydrate or solvate thereof. The compound of the present invention can be used to treat and/or prevent phosphatidylinositol 3-kinase (PI3K) related diseases, such as cancer, cell proliferative diseases and the like.
(FR)La présente invention concerne un composé de quinazolinone deutéré et une composition pharmaceutique le comprenant. En particulier, l'invention porte sur un composé de quinazolinone deutéré et une composition pharmaceutique comprenant le composé, ou une forme cristalline, un sel, un hydrate ou un solvate pharmaceutiquement acceptable de ce dernier. Le composé de la présente invention peut être utilisé pour traiter et/ou prévenir les maladies associées à la phosphatidylinositol 3-kinase (PI3K), telles que le cancer, les maladies de prolifération cellulaire et similaires.
(ZH)本发明涉及氘代的喹唑啉酮化合物以及包含该化合物的药物组合物。具体地,本发明公开了式(I)所示的氘代的喹唑啉酮化合物以及含有该化合物、或其晶型、药学上可接受的盐、水合物或溶剂合物的药物组合物。本发明的化合物可用于治疗和/或预防磷脂酰肌醇3-激酶(PI3K)相关性疾病,例如癌症、细胞增殖性疾病等。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)