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1. (WO2015113451) COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/113451 International Application No.: PCT/CN2015/000054
Publication Date: 06.08.2015 International Filing Date: 28.01.2015
IPC:
C07D 487/04 (2006.01) ,C07D 487/00 (2006.01) ,C07D 403/00 (2006.01) ,C07D 403/02 (2006.01) ,A61K 31/437 (2006.01) ,A61K 31/4375 (2006.01) ,A61P 25/16 (2006.01)
Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED[GB/GB]; 980 Great West Road Brentford Middlesex TW8 9GS, GB
GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED[CN/CN]; Building 3, 898 Halei Road, Zhangjiang High Tech Park Pudong New Area Shanghai 201203, CN (PG)
Inventors: DING, Xiao; CN
LIU, Qian; CN
LONG, Kai; CN
SANG, Yingxia; CN
STASI, Luigi Piero; CN
WAN, Zehong; CN
XU, Qiongfeng; CN
EDGE, Colin Michael; GB
Agent: KING & WOOD MALLESONS; 20th Floor, East Tower, World Financial Centre, No.1 Dongsanhuan Zhonglu, Chaoyang District Beijing 100020, CN
Priority Data:
PCT/CN2014/00014029.01.2014CN
Title (EN) COMPOUNDS
(FR) COMPOSÉS
Abstract:
(EN) Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).
(FR) L'invention concerne des composés qui inhibent l'activité de la kinase LRRK2, des procédés pour leur préparation, des compositions les contenant et leur utilisation dans le traitement ou la prévention de maladies caractérisées par l'activité de la kinase LRRK2, par exemple la maladie de Parkinson, la maladie d'Alzheimer et la sclérose latérale amyotrophique (ALS).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)