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1. (WO2015110707) METHODS AND USES RELATED TO ADAMTS3
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2015/110707 International Application No.: PCT/FI2015/050041
Publication Date: 30.07.2015 International Filing Date: 23.01.2015
IPC:
A61K 38/48 (2006.01) ,C12N 9/64 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
48
acting on peptide bonds (3.4)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
64
derived from animal tissue, e.g. rennin
Applicants:
UNIVERSITY OF HELSINKI [FI/FI]; Yliopistonkatu 4 FI-00014 University of Helsinki, FI
Inventors:
ALITALO, Kari; FI
JELTSCH, Michael; FI
JHA, Sawan Kumar; FI
TVOROGOV, Denis; FI
Agent:
KOLSTER OY AB; (Iso Roobertinkatu 23) P.O.Box 148 FI-00121 Helsinki, FI
Priority Data:
2014507324.01.2014FI
Title (EN) METHODS AND USES RELATED TO ADAMTS3
(FR) PROCÉDÉS ET UTILISATIONS LIÉS À ADAMTS3
Abstract:
(EN) The present invention relates to the utilization of ADAMTS3 metalloprotease. More specifically, the present invention relates to a method of producing fully processed mature VEGF-C polypeptide by a cell and a method of cleaving VEGF-C polypeptides. Furthermore, the present invention relates to different uses of ADAMTS3, ADAMTS3 inhibitors or compositions comprising ADAMTS3 or ADAMTS3 inhibitors, and a method of treating a lymphatic disorder. In addition, the invention relates to a method of producing VEGF-Cbinding molecules.
(FR) La présente invention concerne l’utilisation de la métalloprotéase ADAMTS3. La présente invention concerne plus spécifiquement un procédé de production d’un polypeptide VEGF-C mature totalement traité par une cellule et un procédé de clivage des polypeptides VEGF-C. La présente invention concerne également différentes utilisations d’ADAMTS3, des inhibiteurs d'ADAMTS3 ou des compositions comprenant ADAMTS3 ou des inhibiteurs d’ADAMTS3, et un procédé de traitement d’un trouble lymphatique. La présente invention concerne en outre un procédé de production de molécules liant le VEGF-C.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)