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1. WO2015110707 - METHODS AND USES RELATED TO ADAMTS3

Publication Number WO/2015/110707
Publication Date 30.07.2015
International Application No. PCT/FI2015/050041
International Filing Date 23.01.2015
IPC
A61K 38/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
C12N 9/64 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
64derived from animal tissue, e.g. rennin
CPC
A61K 38/4886
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
4886Metalloendopeptidases (3.4.24), e.g. collagenase
C07K 14/475
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
C12Y 304/24014
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
304Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
24Metalloendopeptidases (3.4.24)
24014Procollagen N-endopeptidase (3.4.24.14)
Applicants
  • UNIVERSITY OF HELSINKI [FI]/[FI]
Inventors
  • ALITALO, Kari
  • JELTSCH, Michael
  • JHA, Sawan Kumar
  • TVOROGOV, Denis
Agents
  • KOLSTER OY AB
Priority Data
2014507324.01.2014FI
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND USES RELATED TO ADAMTS3
(FR) PROCÉDÉS ET UTILISATIONS LIÉS À ADAMTS3
Abstract
(EN)
The present invention relates to the utilization of ADAMTS3 metalloprotease. More specifically, the present invention relates to a method of producing fully processed mature VEGF-C polypeptide by a cell and a method of cleaving VEGF-C polypeptides. Furthermore, the present invention relates to different uses of ADAMTS3, ADAMTS3 inhibitors or compositions comprising ADAMTS3 or ADAMTS3 inhibitors, and a method of treating a lymphatic disorder. In addition, the invention relates to a method of producing VEGF-Cbinding molecules.
(FR)
La présente invention concerne l’utilisation de la métalloprotéase ADAMTS3. La présente invention concerne plus spécifiquement un procédé de production d’un polypeptide VEGF-C mature totalement traité par une cellule et un procédé de clivage des polypeptides VEGF-C. La présente invention concerne également différentes utilisations d’ADAMTS3, des inhibiteurs d'ADAMTS3 ou des compositions comprenant ADAMTS3 ou des inhibiteurs d’ADAMTS3, et un procédé de traitement d’un trouble lymphatique. La présente invention concerne en outre un procédé de production de molécules liant le VEGF-C.
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