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1. (WO2015091851) PROCESS FOR THE PREPARATION OF TIACUMICIN
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CLAIMS

1. A process for the preparation of Tiacumicin B comprising the steps of:

. a) fermentation of a Tiacumicin B producing strain;

b) drying the fermentation broth;

c) extraction of the dried material with a solvent.

2. A process according to claim 1, wherein the broth is spray dried or freeze dried.

3. A process according to claim 1, wherein the broth is spray dried.

4. A process according to claim 1, wherein the broth is freeze dried.

5. A process according to claim 1, wherein the solvent is selected from of C1-C5 alcohols, C4-C6 ethers, C2-C5 ketones or C2-C5 esters.

6. A process according to claim 1, wherein the solvent is selected from methanol, ethanol, isopropanol and acetone.

7. A process according to claim S or 6, wherein the solvent further comprises water.

8. A process according to claim 5 or 6, wherein the solvent further comprises 1-40% v/v water.

9. A process according to claim 5 or 6, wherein the solvent further comprises 10-30% v/v water.

10. A process according to claim 5 or 6, wherein the solvent further comprises 15-20% v/v water.

11. A process according to any of the above claims, further comprising a

chromatography step involving loading of the extraction solution on a column comprising a hydrophobic adsorbent resin, optionally washing before elution.

12. A process according to claim 11 wherein the hydrophobic adsorbent resin is HP20, HP21, HP20SS, SP20, SP20SS, SP825, SP850, SP207, XAD2, XAD7HP, XAD16, XAD16HP, XAD1600, XAD 1180, IRC50 or XAD18.