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1. WO2015091281 - TETRAHYDROTRIAZOLOPYRIMIDINE DERIVATIVES AS HUMAN NEUTROPHIL ELASTASE INHIBITORS

Publication Number WO/2015/091281
Publication Date 25.06.2015
International Application No. PCT/EP2014/077608
International Filing Date 12.12.2014
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
C07D 487/04 (2006.01)
A61K 31/519 (2006.01)
A61P 11/00 (2006.01)
A61P 37/00 (2006.01)
CPC
C07D 487/04
Applicants
  • CHIESI FARMACEUTICI S.P.A. [IT/IT]; Via Palermo, 26/A I-43100 Parma, IT
Inventors
  • ALCARAZ, Lilian; IT
  • SUTTON, Jonathan Mark; IT
  • CAPALDI, Carmelida; IT
  • ARMANI, Elisabetta; IT
Agents
  • MINOJA, Fabrizio; IT
Priority Data
13197370.316.12.2013EP
14172174.612.06.2014EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TETRAHYDROTRIAZOLOPYRIMIDINE DERIVATIVES AS HUMAN NEUTROPHIL ELASTASE INHIBITORS
(FR) DÉRIVÉS DE TÉTRAHYDROTRIAZOLOPYRIMIDINE EN TANT QU'INHIBITEURS DE L'ÉLASTASE NEUTROPHILE HUMAINE
Abstract
(EN)
This invention relates to heterocyclic compounds, which are pyrimidinone derivatives having human neutrophil elastase inhibitory properties, and their use in therapy.
(FR)
L'invention concerne des composés hétérocycliques qui sont des dérivés de la pyrimidinone présentant des propriétés d'inhibition de l'élastase neutrophile humaine, et leur utilisation thérapeutique.
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