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1. WO2015089502 - PASSIVE IMMUNIZATION FOR STAPHYLOCOCCUS INFECTIONS

Publication Number WO/2015/089502
Publication Date 18.06.2015
International Application No. PCT/US2014/070337
International Filing Date 15.12.2014
IPC
A61K 39/40 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
40bacterial
CPC
A61F 2/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02Prostheses implantable into the body
30Joints
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/507
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
507Comprising a combination of two or more separate antibodies
A61K 39/3955
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
3955against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 39/40
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
40bacterial
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants
  • UNIVERSITY OF ROCHESTER [US]/[US]
Inventors
  • DAISS, John, L.
  • SCHWARZ, Edward
  • VARRONE, John, J.
  • BRODELL, James
  • BELLO-IRIZARRY, Sheila, N.
Agents
  • MERKEL, Edwin, V.
Priority Data
61/915,95313.12.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PASSIVE IMMUNIZATION FOR STAPHYLOCOCCUS INFECTIONS
(FR) IMMUNISATION PASSIVE POUR INFECTIONS PAR LE STAPHYLOCOCCUS
Abstract
(EN)
Disclosed herein are monoclonal antibodies or binding portion thereof that bind specifically to a Staphylococcus spp. autolysin N-acetylmuramoyl-L-alanine amidase catalytic domain and/or cell wall binding domain, as well as pharmaceutical compositions containing the same. Cell lines expressing the monoclonal antibodies, including hybridomas, are also disclosed. Methods of using the monoclonal antibodies for installation of orthopedic implants, grafts or medical devices, treating or preventing a Staphylococcus infection, and treating osteomyelitis are described, as are diagnostic methods for the detection of Staphylococcus in a sample.
(FR)
La présente invention concerne des anticorps monoclonaux ou leurs parties de liaison qui se lient spécifiquement à un domaine catalytique d'autolysine N-acétylmuramoyl-L-alanine amidase de Staphylococcus spp. et/ou un domaine de liaison à la paroi cellulaire, ainsi que des compositions pharmaceutiques les contenant. L'invention a également trait à des lignées cellulaires exprimant les anticorps monoclonaux, y compris des hybridomes. L'invention porte en outre sur des procédés d'utilisation des anticorps monoclonaux pour la pose d'implants orthopédiques, de greffes ou de dispositifs médicaux, sur des méthodes de traitement ou de prévention d'une infection par le Staphylococcus, sur des méthodes de traitement de l'ostéomyélite, et sur des procédés de diagnostic pour la détection du Staphylococcus dans un échantillon.
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