Processing

Please wait...

Settings

Settings

Goto Application

1. WO2015089469 - MULTI-EPITOPE TARP PEPTIDE VACCINE AND USES THEREOF

Publication Number WO/2015/089469
Publication Date 18.06.2015
International Application No. PCT/US2014/070144
International Filing Date 12.12.2014
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
CPC
A61K 2039/5154
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
515Animal cells
5154Antigen presenting cells [APCs], e.g. dendritic cells, macrophages
A61K 2039/572
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
57characterised by the type of response, e.g. Th1, Th2
572cytotoxic response
A61K 2039/575
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
57characterised by the type of response, e.g. Th1, Th2
575humoral response
A61K 2039/70
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
70Multivalent vaccine
A61K 39/0011
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0011Cancer antigens
A61K 9/19
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
19lyophilised ; , i.e. freeze-dried, solutions or dispersions
Applicants
  • THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US]/[US]
Inventors
  • WOOD, Lauren, V.
  • BERZOFSKY, Jay, A.
  • ROBERSON, Brenda, D.
  • TERABE, Masaki, R.
Agents
  • CONNOLLY, Jodi, L.
Priority Data
61/915,94813.12.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MULTI-EPITOPE TARP PEPTIDE VACCINE AND USES THEREOF
(FR) VACCIN DE PEPTIDE TARP À MULTIPLES ÉPITOPES, ET SES UTILISATIONS
Abstract
(EN)
The present disclosure describes immunogenic T cell receptor γ alternate reading frame protein (TARP) peptide compositions that include multiple epitopes of the TARP protein. The disclosed compositions can be used for the treatment of TARP-expressing cancers, such as prostate cancer, breast cancer and mesothelioma. In some embodiments, the TARP peptide compositions disclosed herein include sets of overlapping TARP peptides that each have a length of about 15 to about 25 amino acids, and comprise about 5 to about 15 amino acids that are identical to at least another overlapping peptide in the set. In particular examples, the combination of the overlapping TARP peptides in the set encompasses the complete amino acid sequence of human TARP. The multi-epitope peptide compositions described herein include both CD4 and CD8 epitopes, a feature that is important for eliciting CD4+ T cell and CD8+ T cell, as well as humoral immune responses.
(FR)
La présente invention concerne des compositions de peptide protéine à cadre de lecture alternée de récepteur γ de lymphocytes T (TARP) immunogènes, qui comprennent de multiples épitopes de la protéine TARP. Les compositions de l'invention peuvent être utilisées pour le traitement de cancers exprimant TARP, tels que le cancer de la prostate, le cancer du sein et le mésothéliome. Dans certains modes de réalisation, les compositions de peptides TARP de la présente invention comprennent des ensembles de peptides TARP chevauchants qui ont chacun une longueur d'environ 15 à environ 25 acides aminés, et comprennent d'environ 5 à environ 15 acides aminés qui sont identiques à au moins un autre peptide chevauchant de l'ensemble. Dans des exemples particuliers, la combinaison de peptides TARP chevauchants de l'ensemble comprend la séquence entière d'acides aminés de TARP humaine. Les compositions de peptides à multiples épitopes de la présente invention comprennent à la fois des épitopes CD4 et CD8, une caractéristique qui est importante pour déclencher des lymphocytes T CD4+ et des lymphocytes T CD8+, ainsi que des réponses immunitaires humorales.
Latest bibliographic data on file with the International Bureau