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1. WO2015082619 - BENZHYDRYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES

Publication Number WO/2015/082619
Publication Date 11.06.2015
International Application No. PCT/EP2014/076577
International Filing Date 04.12.2014
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
444
containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
C07D 401/14 (2006.01)
C07D 405/14 (2006.01)
C07D 413/14 (2006.01)
C07D 401/12 (2006.01)
C07D 409/14 (2006.01)
C07D 417/14 (2006.01)
CPC
A61K 31/444
A61K 31/4545
A61K 31/496
A61K 9/0075
C07D 401/12
C07D 401/14
Applicants
  • CHIESI FARMACEUTICI S.P.A. [IT/IT]; Via Palermo, 26/A I-43100 Parma, IT
Inventors
  • AMARI, Gabriele; IT
  • ARMANI, Elisabetta; IT
  • DE FANTI, Renato; IT
  • CAPALDI, Carmelida; IT
  • RICCABONI, Mauro; IT
  • BAKER-GLENN, Charles; IT
  • VAN DE PÖEL, Hervé; IT
Agents
  • MINOJA, Fabrizio; IT
Priority Data
13195932.205.12.2013EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BENZHYDRYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES
(FR) DÉRIVÉS BENZHYDRYLE POUR LE TRAITEMENT DE MALADIES RESPIRATOIRES
Abstract
(EN)
The invention relates to novel compounds of formula (I) having a benzhydryl structure which are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
(FR)
L'invention concerne de nouveaux composés de formule (I) à structure benzhydryle, qui sont à la fois des inhibiteurs de l'enzyme phosphodiestérase 4 (PDE4) et des antagonistes des récepteurs muscariniques M3, des procédés de préparation de tels composés, des compositions les contenant et leur utilisation thérapeutique.
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