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1. WO2015073555 - ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS

Publication Number WO/2015/073555
Publication Date 21.05.2015
International Application No. PCT/US2014/065259
International Filing Date 12.11.2014
IPC
C07K 14/305 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
305from Micrococcaceae (F)
CPC
C12N 9/0028
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
0004Oxidoreductases (1.)
0012acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
0026acting on CH-NH groups of donors (1.5)
0028with NAD or NADP as acceptor (1.5.1)
C12P 13/001
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
001Amines; Imines
C12P 17/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
10Nitrogen as only ring hetero atom
C12Y 105/01028
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
105Oxidoreductases acting on the CH-NH group of donors (1.5)
01with NAD+ or NADP+ as acceptor (1.5.1)
01028Opine dehydrogenase (1.5.1.28)
Applicants
  • CODEXIS, INC. [US]/[US]
Inventors
  • AGARD, Nicholas, J.
  • ALVIZO, Oscar
  • MAYO, Melissa, Ann
  • NG MINOR, Stefanie
  • RIGGINS, James, Nicholas
  • MOORE, Jeffrey, C.
Agents
  • MACKNIGHT, Kamrin, T.
Priority Data
61/903,77213.11.2013US
62/022,31509.07.2014US
62/022,32309.07.2014US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
(FR) IMINES RÉDUCTASES MANIPULÉES ET PROCÉDÉS D'AMINATION RÉDUCTRICE DE COMPOSÉS CÉTONIQUES ET AMINÉS
Abstract
(EN)
The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
(FR)
L'invention concerne des polypeptides manipulés présentant une activité imine réductase, des polynucléotides codant les imine réductases manipulées, des cellules hôtes aptes à exprimer les imine réductases manipulées, ainsi que des procédés d'utilisation de ces polypeptides manipulés avec une gamme de composés de substrats cétoniques et aminés dans la préparation de composés de produits d'amines secondaires et tertiaires.
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