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1. (WO2015071334) PICOLINATE CROSS-BRIDGED CYCLAMS, CHELATES WITH METALLIC CATIONS AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/071334 International Application No.: PCT/EP2014/074415
Publication Date: 21.05.2015 International Filing Date: 12.11.2014
IPC:
C07D 487/08 (2006.01) ,A61K 47/22 (2006.01) ,A61K 47/48 (2006.01) ,A61K 51/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
08
Bridged systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
22
Heterocyclic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
Applicants:
UNIVERSITÉ DE BRETAGNE OCCIDENTALE [FR/FR]; 3 rue des Archives F-29238 Brest, FR
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR/FR]; 3 rue Michel-Ange F-75116 Paris, FR
Inventors:
TRIPIER, Raphaël; FR
HALIME, Zakaria; FR
Agent:
ICOSA; 83 avenue Denfert-Rochereau F-75014 Paris, FR
Priority Data:
13192597.612.11.2013EP
Title (EN) PICOLINATE CROSS-BRIDGED CYCLAMS, CHELATES WITH METALLIC CATIONS AND USE THEREOF
(FR) CYCLAMES PONTÉS À BRAS PICOLINATE, CHÉLATES AVEC DES CATIONS MÉTALLIQUES ET LEUR UTILISATION
Abstract:
(EN) The present invention relates to chelates resulting from the complexation of picolinate cross-bridged cyclams of formula (I), wherein n and the substituents L1-L4 and R1-R5 are defined as in the claims, with metallic cations. The invention further relates to picolinate cross-bridged cyclam ligands of formula (I). Another object of the invention is the use of chelates of the invention in nuclear medicine and the use of ligands of the invention in cations detection or epuration of effluents.
(FR) La présente invention concerne des chélates résultant de la complexation de cyclames pontés à bras picolinate de formule (I), dans laquelle n et les substituants L1 à L4 et R1 à R5 sont définis comme dans les revendications, avec des cations métalliques. L'invention concerne en outre des ligands cyclames pontés à bras picolinate de formule (1). Un autre objet de l'invention concerne l'utilisation des chélates de l'invention en médecine nucléaire et l'utilisation des ligands de l'invention dans la détection de cations ou l'épuration d'effluents.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)