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1. (WO2015048744) POLYNUCLEOTIDES ENCODING IMMUNE MODULATING POLYPEPTIDES

Pub. No.:    WO/2015/048744    International Application No.:    PCT/US2014/058311
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Wed Oct 01 01:59:59 CEST 2014
IPC: A61K 31/7088
Applicants: MODERNA THERAPEUTICS, INC.
Inventors: BOLEN, Joseph Beene
FREDERICK, Joshua P.
Title: POLYNUCLEOTIDES ENCODING IMMUNE MODULATING POLYPEPTIDES
Abstract:
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one polypeptide of interest to modulate the immune response. Described herein are compositions, methods, processes, kits and devices for the design, preparation, manufacture and/or formulation of polynucleotides encoding at least one polypeptide of interest which is modulates the activity of the immune system. In one non-limiting embodiment, such polynucleotides take the form or function as modified mRNA molecules which encode at least one polypeptide of interest or variants thereof which modulates the activity of the immune system.