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1. (WO2015048689) INHIBITORS OF BRUTON'S TYROSINE KINASE

Pub. No.:    WO/2015/048689    International Application No.:    PCT/US2014/058132
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Tue Sep 30 01:59:59 CEST 2014
IPC: C07D 403/14
C07D 401/14
A61K 31/519
A61P 19/02
A61P 19/00
Applicants: PHARMACYCLICS LLC
Inventors: WANG, Longcheng
CHEN, Wei
JIA, Zhaozhong, J.
LOURY, David, J.
Title: INHIBITORS OF BRUTON'S TYROSINE KINASE
Abstract:
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.