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1. (WO2015048535) PRENATAL DIAGNOSTIC RESTING STANDARDS

Pub. No.:    WO/2015/048535    International Application No.:    PCT/US2014/057843
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Sat Sep 27 01:59:59 CEST 2014
IPC: C12Q 1/68
Applicants: NATERA, INC.
Inventors: BABIARZ, Joshua
ZIMMERMAN, Bernhard
Title: PRENATAL DIAGNOSTIC RESTING STANDARDS
Abstract:
Embodiments of the invention include methods and compositions for producing proficiency testing standards for noninvasive prenatal genetic diagnostics and for the detection and monitoring of cancer. The compositions can comprise a plurality of different nucleosomal DNA fragments derived from either primary cells or cell lines. The amount of the different nucleosomal DNA fragments can be varied so as to simulate naturally occurring cell free DNA samples obtained from the blood of the pregnant woman or naturally occurring cell free DNA samples obtained from the blood of cancer patients.