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1. (WO2015048149) SELF-ASSEMBLED NANOPARTICLE VACCINES

Pub. No.:    WO/2015/048149    International Application No.:    PCT/US2014/057240
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Thu Sep 25 01:59:59 CEST 2014
IPC: A61K 39/155
C07K 14/135
C07K 14/47
A61K 39/02
A61K 39/12
Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventors: SASISEKHARAN, Ram
RAGURAM, Aditya
SUBRAMANIAN, Vidya
Title: SELF-ASSEMBLED NANOPARTICLE VACCINES
Abstract:
The present invention provides nanoparticles and compositions of various constructs that combine meta-stable viral proteins (e.g., RSV F protein) and self-assembling molecules (e.g., ferritin, HSPs) such that the pre-fusion conformational state of these key viral proteins is preserved (and locked) along with the protein self-assembling into a polyhedral shape, thereby creating nanoparticles that are effective vaccine agents. The invention also provides nanoparticles comprising a viral fusion protein, or fragment or variant thereof, and a self- assembling molecule, and immunogenic and vaccine compositions including the same.