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1. WO2015048145 - COMPOSITIONS AND METHODS FOR REDUCING ANTIGEN-SPECIFIC IMMUNOGENICITY

Publication Number WO/2015/048145
Publication Date 02.04.2015
International Application No. PCT/US2014/057234
International Filing Date 24.09.2014
IPC
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07F 9/09 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P-C bonds
08Esters of oxyacids of phosphorus
09Esters of phosphoric acids
CPC
A61K 2039/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 2039/55511
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
A61K 2039/55555
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
A61K 2039/577
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
57characterised by the type of response, e.g. Th1, Th2
577tolerising response
A61K 39/0008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0008Antigens related to auto-immune diseases; Preparations to induce self-tolerance
Applicants
  • THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK [US]/[US]
Inventors
  • BALU-IYER, Sathy
  • KOSLOSKI, Matthew, P.
  • SHETTY, Krithika, Arun
  • SCHNEIDER, Jennifer, Leigh
  • FATHALLAH, Anas
Agents
  • WATT, Rachel, S.
Priority Data
61/881,85724.09.2013US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR REDUCING ANTIGEN-SPECIFIC IMMUNOGENICITY
(FR) COMPOSITIONS ET MÉTHODES POUR RÉDUIRE L'IMMUNOGÉNICITÉ SPÉCIFIQUE D'ANTIGÈNE
Abstract
(EN) Provided are method for inducing immune tolerance to antigens including therapeutic antigens. The method comprises administering to an individual OPLS or other lipidic compositions and the antigen, either in a single formulation or as separate formulations where the separate formulations are administered concomitantly or sequentially.
(FR) La présente invention concerne une méthode pour induire une tolérance immunitaire à des antigènes, y compris à des antigènes thérapeutiques. Cette méthode consiste à administrer, à un individu, OPLS ou d'autres compositions lipidiques et l'antigène, soit dans une formulation unique ou sous forme de formulations séparées, les formulations séparées étant administrées simultanément ou séquentiellement.
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