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1. (WO2015048020) COMPOSITIONS AND METHODS FOR THE MANUFACTURE OF LIPID NANOPARTICLES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/048020 International Application No.: PCT/US2014/056984
Publication Date: 02.04.2015 International Filing Date: 23.09.2014
IPC:
A61K 9/127 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
Applicants:
ALNYLAM PHARMACEUTICALS, INC. [US/US]; 300 Third Street Cambridge, Massachusetts 02142, US
Inventors:
NECHEV, Lubomir; US
PRICE, Stuart; US
Agent:
WARD, Donna T.; US
Priority Data:
61/881,63024.09.2013US
Title (EN) COMPOSITIONS AND METHODS FOR THE MANUFACTURE OF LIPID NANOPARTICLES
(FR) COMPOSITIONS ET PROCÉDÉS DE FABRICATION DE NANOPARTICULES LIPIDIQUES
Abstract:
(EN) The invention relates to methods, processes and apparatuses for the manufacture of lipid nanoparticles having a therapeutic payload. The methods and systems of the present invention are useful in the manufacture of lipid nanoparticles for formulating an RNAi agent payload, wherein the RNAi agent is selected from the group consisting of siRNA, dsRNA, miRNA, and nucleotide sequences encoding the same.
(FR) L'invention concerne des procédés, des processus et des appareils pour la fabrication de nanoparticules lipidiques ayant une charge utile thérapeutique. Les procédés et systèmes de la présente invention servent à la fabrication de nanoparticules lipidiques utilisées pour formuler une charge utile d'agent d'interférence ARN, l'agent d'interférence ARN étant choisi dans le groupe constitué par l'ARN interférent court, l'ARN double brin, le micro-ARN et les séquences nucléotidiques codant pour ceux-ci.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)